Article

PaSD-qc: Quality control for single cell whole-genome sequencing data using power spectral density estimation

2017-07-21

Abstract excerpt

Single cell whole-genome sequencing (scWGS) is providing novel insights into the nature of genetic heterogeneity in normal and diseased cells. However, scWGS introduces DNA amplification-related biases that can confound downstream analysis. Here we present a statistical method, with an accompanying package PaSD-qc ( P ower S pectral D ensity-qc), that evaluates the quality of single cell libraries. It uses a mo...

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Literature Corpus work: ec1e0be0-7b60-5618-8943-3f82aacb5683
DOI: 10.1101/166637

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