Article
ddClone: joint statistical inference of clonal populations from single cell and bulk tumour sequencing data.
Genome biology - 1 Mar 2017
Salehi Sohrab, Steif Adi, Roth Andrew, Aparicio Samuel, Bouchard-Côté Alexandre, Shah Sohrab P
Abstract excerpt
Next-generation sequencing (NGS) of bulk tumour tissue can identify constituent cell populations in cancers and measure their abundance. This requires computational deconvolution of allelic counts from somatic mutations, which may be incapable of fully resolving the underlying population structure. Single cell sequencing (SCS) is a more direct method, although its replacement of NGS is impeded by technical noise...
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