Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Accucopy: accurate and fast inference of allele-specific copy number alterations from low-coverage low-purity tumor sequencing data.

BMC bioinformatics - 15 Jan 2021

Fan Xinping, Luo Guanghao, Huang Yu S

Abstract excerpt

BACKGROUND: Copy number alterations (CNAs), due to their large impact on the genome, have been an important contributing factor to oncogenesis and metastasis. Detecting genomic alterations from the shallow-sequencing data of a low-purity tumor sample remains a challenging task. RESULTS: We introduce Accucopy, a method to infer total copy numbers (TCNs) and allele-specific copy numbers (ASCNs) from challenging...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Algorithms
Share to Alleles
Share to Bayes Theorem

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Copy Number Variations

Share to High-Throughput Nucleotide Sequencing

Share to Neoplasms

Share to Software

Source

Open in PubMed Open full text

Identifiers

PMID: 33451280
DOI: 10.1186/s12859-020-03924-5
PMCID: PMC7811225

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Accucopy: accurate and fast inference of allele-specific copy number alterations from low-coverage low-purity tumor sequencing data.PMID 33451280Read ↗

Accucopy: Accurate and Fast Inference of Allele-specific Copy Number Alterations from Low-coverage Low-purity Tumor Sequencing DataSemantic proximity Read ↗

Improved allele-specific single-cell copy number estimation in low-coverage DNA-sequencing.Semantic proximity Read ↗

Tracing the evolution of aneuploid cancers by multiregional sequencing with CRUST.Semantic proximity Read ↗

SCONCE: a method for profiling copy number alterations in cancer evolution using single-cell whole genome sequencingSemantic proximity Read ↗

CNApp, a tool for the quantification of copy number alterations and integrative analysis revealing clinical implications.Semantic proximity Read ↗

CANCAN: high-resolution copy number and mutation heterogeneity analysis of DNA sequence data for clinical applicationsSemantic proximity Read ↗

Phertilizer: Growing a clonal tree from ultra-low coverage single-cell DNA sequencing of tumorsSemantic proximity Read ↗

Integrative pipeline for profiling DNA copy number and inferring tumor phylogenySemantic proximity Read ↗

FACETS: Fraction and Allele-Specific Copy Number Estimates from Tumor Sequencing.Semantic proximity Read ↗

Integrative pipeline for profiling DNA copy number and inferring tumor phylogeny.Semantic proximity Read ↗

The Tangent copy-number inference pipeline for cancer genome analysesSemantic proximity Read ↗

Resolving single-cell copy number profiling for large datasetsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.