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Accucopy: Accurate and Fast Inference of Allele-specific Copy Number Alterations from Low-coverage Low-purity Tumor Sequencing Data

2020-01-03

Abstract excerpt

<h4>Background</h4> Copy number alterations (CNAs), due to their large impact on the genome, have been an important contributing factor to oncogenesis and metastasis. Detecting genomic alterations from the shallow-sequencing data of a low-purity tumor sample remains a challenging task. <h4>Results</h4> We introduce Accucopy, a method to infer total copy numbers (TCNs) and allele-specific copy numbers (ASCNs) fro...

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Literature Corpus work: 576d6bcc-7e42-5af8-b11d-f2122f0fa0ec
DOI: 10.1101/2020.01.02.892364

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