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Performance of four modern whole genome amplification methods for copy number variant detection in single cells

7 Jun 2017

Abstract excerpt

Whole genome amplification (WGA) has become an invaluable tool to perform copy number variation (CNV) detection in single, or a limited number of cells. Unfortunately, current WGA methods introduce representation bias that limits the detection of small CNVs. New WGA methods have been introduced that might have the potential to reduce this bias. We compared the performance of PicoPLEX DNA-Seq (Picoseq), DOPlify,...

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PMID: 28611458
DOI: 10.1038/s41598-017-03711-y

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