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Single-Cell Whole-Genome Amplification and Sequencing: Methodology and Applications

13 Jun 2015

Abstract excerpt

We present a survey of single-cell whole-genome amplification (WGA) methods, including degenerate oligonucleotide-primed polymerase chain reaction (DOP-PCR), multiple displacement amplification (MDA), and multiple annealing and looping-based amplification cycles (MALBAC). The key parameters to characterize the performance of these methods are defined, including genome coverage, uniformity, reproducibility,...

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PMID: 26077818
DOI: 10.1146/annurev-genom-090413-025352

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