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Article

Calibrating genomic and allelic coverage bias in single-cell sequencing.

Nature communications - 16 Apr 2015

Zhang Cheng-Zhong, Adalsteinsson Viktor A, Francis Joshua, Cornils Hauke, Jung Joonil, Maire Cecile, Ligon Keith L, Meyerson Matthew, Love J Christopher

Abstract excerpt

Artifacts introduced in whole-genome amplification (WGA) make it difficult to derive accurate genomic information from single-cell genomes and require different analytical strategies from bulk genome analysis. Here, we describe statistical methods to quantitatively assess the amplification bias resulting from whole-genome amplification of single-cell genomic DNA. Analysis of single-cell DNA libraries generated by...

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PMID: 25879913
DOI: 10.1038/ncomms7822
PMCID: PMC4922254

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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