TRIDENT: a framework for robust multi-trait GWAS identifies 66 novel multi-trait osteoarthritis signals

Abstract excerpt

As multi-trait genome-wide association studies (GWAS) are increasingly used to identify shared genetic associations across related phenotypes, practical approaches to assess the robustness of their findings are lacking. Here we present a three-step framework (Trident) for robust multi-trait GWAS that uses an earlier, smaller GWAS meta-analysis to test whether phenotypes can be validly combined as well as the lates...

Topics

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• Gene Expression Profiling
• Gene Expression Regulation
• Genetic Predisposition to Disease
• Genome-Wide Association Study
• Osteoarthritis
• Quantitative Trait Loci
• Transcription Factors
• Transcriptome

Identifiers and source

Literature Corpus work

ec04f774-2f59-5d6f-812f-57be507a968a

DOI

10.64898/2026.08.12.26360256