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Genetics of osteoarthritis: Insights from GWAS to therapeutic opportunities.

Osteoarthritis and cartilage - 1 Aug 2026

Hatzikotoulas Konstantinos, Southam Lorraine, Zeggini Eleftheria

Abstract excerpt

OBJECTIVE: Osteoarthritis is the most common joint disease and a leading cause of pain and disability worldwide, affecting both weight-bearing and non-weight-bearing joints. Osteoarthritis is a complex polygenic disease shaped by genetic, molecular, and environmental factors. DESIGN AND RESULTS: Large-scale genome-wide association studies, enabled by global biobanks and international collaboration, have...

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Genetic Predisposition to Disease
Genome-Wide Association Study
Osteoarthritis

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 42128200
DOI: 10.1016/j.joca.2026.05.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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