Article
Novel insight into the aetiology of rheumatoid arthritis gained by a cross-tissue transcriptome-wide association study.
RMD open - 1 Sept 2022
Ni Jing, Wang Peng, Yin Kang-Jia, Yang Xiao-Ke, Cen Han, Sui Cong, Wu Guo-Cui, Pan Hai-Feng
Abstract excerpt
BACKGROUND: Although genome-wide association studies (GWASs) have identified more than 100 loci associated with rheumatoid arthritis (RA) susceptibility, the causal genes and biological mechanisms remain largely unknown. METHODS: A cross-tissue transcriptome-wide association study (TWAS) using the unified test for molecular signaturestool was performed to integrate GWAS summary statistics from 58 284 individuals...
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