Article
Translating Osteoarthritis Genetic Risk Into Biomarkers: Opportunities, Pitfalls, and Implementation Considerations.
Human mutation - 1 Jan 2026
Meng Tao, Ma Lina, Zhang Xiaoqing, Han Jinchang, Li Fuyuan, Wu Weiyong, Liu Shilong, Liu Aifeng
Abstract excerpt
Osteoarthritis (OA) is a heterogeneous joint disease in which patients differ widely in onset, progression, pain burden, and inflammatory activity, yet clinical tools for early risk stratification and mechanism-informed subtyping remain limited. Human genetic studies have identified many OA-associated loci, but translation into deployable biomarkers has been slow because most signals are polygenic, largely...
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