Article

Alterations in the Brain Lipidome of Alzheimer’s Disease Donors with Rare TREM2 Risk Variants

2024-08-22

Abstract excerpt

TREM2 is a microglial receptor, sensitive to Phospholipids and Sphingomyelins, associated with neurodegeneration. Hypomorphic variants in the TREM2 gene significantly increase the risk of developing AD. The main aim of this study was to characterize networks of lipids in post-mortem brain from AD and control donors, and to identify key lipids that are associated with AD and impacted by dysfunctional TREM2. We stud...

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Literature Corpus work: ebf5476f-b87a-5587-8c51-8ca3016f8313
DOI: 10.1101/2024.08.22.24311238

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