Article
TREM2 impacts brain microglia, oligodendrocytes and endothelial co-expression modules revealing genes and pathways important in Alzheimer’s disease
2021-07-17
Abstract excerpt
A microglia response to pathogenic signals in diseases such as Alzheimer’s disease (AD) has long been recognised, but recent genetic findings have cemented their direct causal contribution to AD and thus the potential to target them or their effector pathways as a possible treatment strategy. TREM2 is a highly penetrant microglia risk gene for AD, which appears central to the coordination of the damage response by...
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Identifiers and source
- Literature Corpus work
- 46aa5b11-93b6-5062-920c-a8625ed00d5a
- DOI
- 10.1101/2021.07.16.452732