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Article

The TREM2 R47H variant is associated with liver-plasma-brain axis dyshomeostasis in the 5xFAD mouse model of Alzheimer's disease.

Neurobiology of aging - 1 Sept 2026

Faraci Gina, Goodfriend Benjamin, Bishop Joseph, Vu Michael, Avelar-Barragan Julio, Dunham Sage J B, Rothman Jason A, Whiteson Katrine L, Cheema Amrita K, Milinkeviciute Giedre, Tenner Andrea J, LaFerla Frank M, MacGregor Grant R, Green Kim N, Mapstone Mark

Abstract excerpt

The human Triggering Receptor Expressed on Myeloid cells 2 (TREM2) gene is expressed predominantly by microglia in the brain and the R47H coding variant of TREM2 is associated with increased risk for late-onset Alzheimer's disease (LOAD). We performed lipidomic and metabolomic analysis of liver, plasma, and brain in 4- and 12-month-old Trem2R47H homozygous (n = 27), 5xFAD hemizygous (n = 63), 5xFAD hemizygous,...

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Identifiers

PMID: 42102578
DOI: 10.1016/j.neurobiolaging.2026.04.007
PMCID: PMC13249471

Genes

TREM2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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