Article

Cholesterol differentially regulates α-synuclein binding across membrane packing regimes

2026-05-26

Abstract excerpt

α-Synuclein (αSyn) is an intrinsically disordered protein that preferentially binds anionic membranes with lipid packing defects. Cholesterol is an abundant membrane component that regulates packing and organization within membranes, yet its effect on αSyn binding remains unclear as prior studies report both cholesterol-mediated enhancement and suppression. Here, we investigated whether these conflicting effects r...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ebd2e303-df9c-5408-a3ee-fc9e39710ec5
DOI: 10.64898/2026.05.21.726870

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cholesterol differentially regulates α-synuclein binding across membrane packing regimesDOI 10.64898/2026.05.21.726870Read

Effects of curvature and composition on α-synuclein binding to lipid vesicles.Semantic proximity Read

Alpha-synuclein selectively binds to anionic phospholipids embedded in liquid-disordered domains.Semantic proximity Read

α-Synuclein acts as a cholesteryl-ester sensor on lipid droplets regulating organelle size and abundanceSemantic proximity Read

Interaction of Alpha-Synuclein and Its Mutants with Rigid Lipid Vesicle Mimics of Varying Surface Curvature.Semantic proximity Read

Self-limiting multimerization of α-synuclein on membrane and its implication in Parkinson's diseases.Semantic proximity Read

Cell membranes sustain phospholipid imbalance via cholesterol asymmetrySemantic proximity Read

Parkinson's disease-associated mutations in α-synuclein alters its lipid-bound state.Semantic proximity Read

A pathogenic mutation in α-SNAP impairs membrane lipid binding by concealing a critical hydrophobic loop.Semantic proximity Read

A combinatorial code for the interaction of alpha-synuclein with membranes.Semantic proximity Read

Probing Membrane Association of α-Synuclein Domains with VDAC Nanopore Reveals Unexpected Binding PatternSemantic proximity Read

Lipid Acyl Chain-Driven α-Synuclein Fibril Polymorphisms and Neuronal PathologiesSemantic proximity Read

Missense mutations on SynGAP C2 domain impair membrane diffusionSemantic proximity Read