Article
Interaction of Alpha-Synuclein and Its Mutants with Rigid Lipid Vesicle Mimics of Varying Surface Curvature.
ACS nano - 25 Aug 2020
McClain Sophia M, Ojoawo Adedolapo M, Lin Wayne, Rienstra Chad M, Murphy Catherine J
Abstract excerpt
Abnormal aggregation of alpha-synuclein (α-syn), an intrinsically disordered neuronal protein, is strongly implicated in the development of Parkinson's disease. Efforts to better understand α-syn's native function and its pathogenic role in neurodegeneration have revealed that the protein interacts with anionic lipid vesicles via adoption of an amphipathic α-helical structure; however, the ability of α-syn to...
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