Article

Missense mutations on SynGAP C2 domain impair membrane diffusion

2025-11-28

Abstract excerpt

SYNGAP1 mutations have been linked to a range of neuropathological disorders and, more recently, to the insurgence of cancer. Despite its emerging relevance, the molecular basis of SynGAP’s action remains poorly understood. Here, using extensive molecular dynamics simulations integrated with structural analysis, we define how the SynGAP C2 domain associates with lipid bilayers. In particular, we observed spontaneo...

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Literature Corpus work: 035f6b44-26c7-5f35-b762-e147189acae2
DOI: 10.1101/2025.11.27.690967

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