Article
MHCSeqNet2-improved peptide-class I MHC binding prediction for alleles with low data.
Bioinformatics (Oxford, England) - 2 Jan 2024
Wongklaew Patiphan, Sriswasdi Sira, Chuangsuwanich Ekapol
Abstract excerpt
MOTIVATION: The binding of a peptide antigen to a Class I major histocompatibility complex (MHC) protein is part of a key process that lets the immune system recognize an infected cell or a cancer cell. This mechanism enabled the development of peptide-based vaccines that can activate the patient's immune response to treat cancers. Hence, the ability of accurately predict peptide-MHC binding is an essential...
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