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Article

Deep learning pan-specific model for interpretable MHC-I peptide binding prediction with improved attention mechanism.

Proteins - 1 Jul 2021

Jin Jing, Liu Zhonghao, Nasiri Alireza, Cui Yuxin, Louis Stephen-Yves, Zhang Ansi, Zhao Yong, Hu Jianjun

Abstract excerpt

Accurate prediction of peptide binding affinity to the major histocompatibility complex (MHC) proteins has the potential to design better therapeutic vaccines. Previous work has shown that pan-specific prediction algorithms can achieve better prediction performance than other approaches. However, most of the top algorithms are neural networks based black box models. Here, we propose DeepAttentionPan, an improved...

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PMID: 33594723
DOI: 10.1002/prot.26065

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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