Article

Cross-ancestry performance of Parkinson’s disease polygenic risk scores in admixed Latin American populations

2026-03-03

Abstract excerpt

<h4>ABSTRACT</h4> Parkinson’s disease (PD) is a disabling neurodegenerative disorder with a substantial heritable component. Despite major advances in genome-wide association studies (GWAS), polygenic risk scores (PRS) show reduced predictive performance outside European populations, limiting equitable translation. Latin American populations represent a particularly difficult case because of their characteristic...

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Literature Corpus work: ebbb8616-7c82-5395-bf06-850728d73d81
DOI: 10.64898/2026.03.02.26347226

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