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Article

Polygenic risk scores and Parkinson's disease in South Africa advancing ancestry informed disease prediction.

PLoS genetics - 1 Mar 2026

Step Kathryn, Ndong Sima Carene Anne Alene, Grant Spencer, Kim Jonggeol Jeffrey, Waldo Emily, Bardien Soraya, Mata Ignacio F

Abstract excerpt

Parkinson's disease (PD) is a complex neurodegenerative disorder with environmental and genetic influences. Using genotyping array data of 661 South African PD cases and 737 controls, we conduct a polygenic risk score (PRS) analysis using PRSice-2. Summary statistics from two PD association studies have been used as base datasets. We split the target dataset into training (70%; n = 979) and validation (30%;...

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Identifiers

PMID: 41801886
DOI: 10.1371/journal.pgen.1012064
PMCID: PMC12987585

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