Article

Distinct Nrf2 Signaling Thresholds Mediate Lung Tumor Initiation and Progression

2022-08-24

Abstract excerpt

<h4>ABSTRACT</h4> Mutations in the KEAP1-NRF2 pathway occur in up to a third of non-small cell lung cancer (NSCLC) cases and often confer resistance to therapy and poor outcomes. Here, we developed murine alleles of the KEAP1 and NRF2 mutations found in human NSCLC and comprehensively interrogated their impact on tumor initiation and progression. Chronic Nrf2 stabilization by Keap1 or Nrf2 mutation was not suffic...

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Literature Corpus work: eb53e412-bd58-569f-a1fb-eb679a8bf5f9
DOI: 10.1101/2022.08.24.504986

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