Article

Activating NRF2E79Q mutation alters the differentiation of human non-small cell lung cancer

2025-05-15

Abstract excerpt

<title>Abstract</title> <p>The NRF2 signaling pathway promotes tumor initiation, progression and resistance to chemotherapy, radiation therapy and immune checkpoint inhibitors. The mechanisms underlying the biology of NRF2-active tumors are varied, and include altered cellular metabolism, a reductive shift in redox state, and immunosuppression. Here we determined the molecular and phenotypic impact of NRF2 activa...

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Literature Corpus work: c526243c-0b61-5406-a3e9-9c9c85b3ac4c
DOI: 10.21203/rs.3.rs-6606334/v1

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