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Article

KEAP1-Mutant NSCLC: The Catastrophic Failure of a Cell-Protecting Hub.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Jun 2022

Scalera Stefano, Mazzotta Marco, Cortile Clelia, Krasniqi Eriseld, De Maria Ruggero, Cappuzzo Federico, Ciliberto Gennaro, Maugeri-Saccà Marcello

Abstract excerpt

Mutations in the KEAP1-NRF2 pathway are common in NSCLC, albeit with a prevalence of KEAP1 mutations in lung adenocarcinoma and an equal representation of KEAP1 and NFE2L2 (the gene encoding for NRF2) alterations in lung squamous cell carcinoma. The KEAP1-NRF2 axis is a crucial modulator of cellular homeostasis, enabling cells to tolerate oxidative and metabolic stresses, and xenobiotics. The complex...

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Identifiers

PMID: 35351670
DOI: 10.1016/j.jtho.2022.03.011

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KEAP1-Mutant NSCLC: The Catastrophic Failure of a Cell-Protecting Hub.PMID 35351670Read ↗

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FSP1 and NRF2 independently contribute to ferroptosis resistance in KEAP1 mutant non-small cell lung carcinomaSemantic proximity Read ↗

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NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer.Semantic proximity Read ↗

Targeting ubiquitin signaling vulnerabilities in KEAP1-inactivated lung cancer.Semantic proximity Read ↗

Double vulnerability of active-NRF2 lung squamous cell carcinoma to NRF2 and TRIM24Semantic proximity Read ↗

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