Article
Activating NRF2E79Q mutation alters the differentiation of human non-small cell lung cancer.
Cancer gene therapy - 1 Dec 2025
Hamad Samera H, Joshi Hansa, Hess T, Jefferys Stuart R, Saleh Zena, Bendjilali Nasrine, Sellers Rani S, Zhu Gord, Shrank Travis, Moore Rayvon T, Corcoran David, Simon Jeremy M, Spitz Francis R, Shersher David, Major Michael B, Weissman Bernard E
Abstract excerpt
The NRF2 signaling pathway promotes tumor initiation, progression and resistance to chemotherapy, radiation therapy and immune checkpoint inhibitors. The mechanisms underlying the biology of NRF2-active tumors are varied and include altered cellular metabolism, a reductive shift in redox state, and immunosuppression. Here we determined the molecular and phenotypic impact of NRF2 activation on two human non-small...
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