Article

Loss-of-function mutations in KEAP1 drive lung cancer progression via KEAP1/NRF2 pathway activation

2020-03-19

Abstract excerpt

<h4>Background: </h4> and Purpose: Targeted therapy and immunotherapy have led to dramatic change in the treatment of lung cancer, however, the overall 5-year survival rate of lung cancer patients is still suboptimal. It is important to exploit new potential of molecularly targeted therapies. High-frequency somatic mutations in KEAP1/NRF2 (27.9%) have been identified in lung squamous cell carcinoma. In this resear...

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Literature Corpus work: bc7f40b7-9179-5c41-ad0f-9d98aa4fec8c
DOI: 10.21203/rs.2.18320/v2

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