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Article

Role of KEAP1/NRF2 and TP53 Mutations in Lung Squamous Cell Carcinoma Development and Radiation Resistance.

Cancer discovery - 1 Jan 2017

Jeong Youngtae, Hoang Ngoc T, Lovejoy Alexander, Stehr Henning, Newman Aaron M, Gentles Andrew J, Kong William, Truong Diana, Martin Shanique, Chaudhuri Aadel, Heiser Diane, Zhou Li, Say Carmen, Carter Justin N, Hiniker Susan M, Loo Billy W, West Robert B, Beachy Philip, Alizadeh Ash A, Diehn Maximilian

Abstract excerpt

Lung squamous cell carcinoma (LSCC) pathogenesis remains incompletely understood, and biomarkers predicting treatment response remain lacking. Here, we describe novel murine LSCC models driven by loss of Trp53 and Keap1, both of which are frequently mutated in human LSCCs. Homozygous inactivation of Keap1 or Trp53 promoted airway basal stem cell (ABSC) self-renewal, suggesting that mutations in these genes lead...

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Share to Carcinoma, Squamous Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kelch-Like ECH-Associated Protein 1

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Share to NF-E2-Related Factor 2

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Source

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Identifiers

PMID: 27663899
DOI: 10.1158/2159-8290.CD-16-0127
PMCID: PMC5222718

Genes

KEAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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