Article

LZTR1 functions as a two-hit tumor suppressor in childhood acute lymphoblastic leukemia

2026-06-29

Abstract excerpt

LZTR1 negatively regulates RAS family proteins via proteasomal degradation. Germline loss-of-function variants cause Noonan syndrome, with emerging evidence implicating LZTR1 in predisposition to childhood acute lymphoblastic leukemia (ALL), though its role in hematopoiesis remains poorly defined. Screening 1,587 children with ALL identified LZTR1 variants in 44 patients (2.8%). Germline variants were detected in...

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Literature Corpus work: eb4ad4a1-7c17-511a-b77c-d474e16495de
DOI: 10.64898/2026.06.26.26356641

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