Article

Germline <i>RUNX1</i> Variation and Predisposition to Childhood Acute Lymphoblastic Leukemia

2021-05-04

Abstract excerpt

RUNX1 is a transcription factor critical for definitive hematopoiesis and genetic alterations in RUNX1 have been implicated in both benign and malignant blood disorders, particularly of the megakaryocyte and myeloid lineages. Somatic RUNX1 mutations are reported in B- and T-cell acute lymphoblastic leukemia (B-ALL and T-ALL), but germline genetic variation of RUNX1 in these lymphoid malignancies have not been comp...

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Literature Corpus work: 89157d37-3fde-501c-8f0a-ec65462408db
DOI: 10.1101/2021.04.29.21256340

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