Article
Molecular basis of ETV6-mediated predisposition to childhood acute lymphoblastic leukemia.
Blood - 21 Jan 2021
Nishii Rina, Baskin-Doerfler Rebekah, Yang Wentao, Oak Ninad, Zhao Xujie, Yang Wenjian, Hoshitsuki Keito, Bloom Mackenzie, Verbist Katherine, Burns Melissa, Li Zhenhua, Lin Ting-Nien, Qian Maoxiang, Moriyama Takaya, Gastier-Foster Julie M, Rabin Karen R, Raetz Elizabeth, Mullighan Charles, Pui Ching-Hon, Yeoh Allen Eng-Juh, Zhang Jinghui, Metzger Monika L, Klco Jeffery M, Hunger Stephen P, Newman Scott, Wu Gang, Loh Mignon L, Nichols Kim E, Yang Jun J
Abstract excerpt
There is growing evidence supporting an inherited basis for susceptibility to acute lymphoblastic leukemia (ALL) in children. In particular, we and others reported recurrent germline ETV6 variants linked to ALL risk, which collectively represent a novel leukemia predisposition syndrome. To understand the influence of ETV6 variation on ALL pathogenesis, we comprehensively characterized a cohort of 32 childhood...
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