Article
The genomic landscape of pediatric acute lymphoblastic leukemia.
Nature genetics - 1 Sept 2022
Brady Samuel W, Roberts Kathryn G, Gu Zhaohui, Shi Lei, Pounds Stanley, Pei Deqing, Cheng Cheng, Dai Yunfeng, Devidas Meenakshi, Qu Chunxu, Hill Ashley N, Payne-Turner Debbie, Ma Xiaotu, Iacobucci Ilaria, Baviskar Pradyuamna, Wei Lei, Arunachalam Sasi, Hagiwara Kohei, Liu Yanling, Flasch Diane A, Liu Yu, Parker Matthew, Chen Xiaolong, Elsayed Abdelrahman H, Pathak Omkar, Li Yongjin, Fan Yiping, Michael J Robert, Rusch Michael, Wilkinson Mark R, Foy Scott, Hedges Dale J, Newman Scott, Zhou Xin, Wang Jian, Reilly Colleen, Sioson Edgar, Rice Stephen V, Pastor Loyola Victor, Wu Gang, Rampersaud Evadnie, Reshmi Shalini C, Gastier-Foster Julie, Guidry Auvil Jaime M, Gesuwan Patee, Smith Malcolm A, Winick Naomi, Carroll Andrew J, Heerema Nyla A, Harvey Richard C, Willman Cheryl L, Larsen Eric, Raetz Elizabeth A, Borowitz Michael J, Wood Brent L, Carroll William L, Zweidler-McKay Patrick A, Rabin Karen R, Mattano Leonard A, Maloney Kelly W, Winter Stuart S, Burke Michael J, Salzer Wanda, Dunsmore Kimberly P, Angiolillo Anne L, Crews Kristine R, Downing James R, Jeha Sima, Pui Ching-Hon, Evans William E, Yang Jun J, Relling Mary V, Gerhard Daniela S, Loh Mignon L, Hunger Stephen P, Zhang Jinghui, Mullighan Charles G
Abstract excerpt
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Here, using whole-genome, exome and transcriptome sequencing of 2,754 childhood patients with ALL, we find that, despite a generally low mutation burden, ALL cases harbor a median of four putative somatic driver alterations per sample, with 376 putative driver genes identified varying in prevalence across ALL subtypes. Most samples harbor at...
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