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Article

RUNX1 Alterations in Pediatric Myeloid Malignancies: Divergent Germline and Somatic Trajectories.

International journal of molecular sciences - 26 May 2026

Bicǎ Ana Maria, Marcu Andra Daniela, Jercan Cristina Georgiana, Radu Letiția Elena, Avramescu Irina, Jardan Cerasela, Jardan Dumitru, Cǎlugǎru Onda Tabita, Mambet Cristina, Colițǎ Anca

Abstract excerpt

RUNX1 alterations contribute to pediatric myeloid malignancies through both germline predisposition syndromes and somatic leukemogenic events, but their clinical and biological significance in children remains incompletely defined. This retrospective single-center study evaluated six pediatric patients with myelodysplastic syndromes or acute leukemias harboring RUNX1 variants, integrating clinical, cytogenetic,...

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Topics

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Share to Child, Preschool
Share to Chromosome Deletion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 7

Share to Core Binding Factor Alpha 2 Subunit

Share to Germ-Line Mutation

Share to High-Throughput Nucleotide Sequencing

Share to Leukemia, Myeloid, Acute

Share to Myelodysplastic Syndromes

Source

Open in PubMed Open full text

Identifiers

PMID: 42278335
DOI: 10.3390/ijms27114805
PMCID: PMC13256105

Genes

RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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