Article

Human-specific paralogs of SRGAP2 induce neotenic features of microglia structural and functional maturation

2024-06-29

Abstract excerpt

<h4>SUMMARY</h4> Microglia play key roles in shaping synaptic connectivity during neural circuits development. Whether microglia display human-specific features of structural and functional maturation is currently unknown. We show that the ancestral gene SRGAP2A and its human-specific (HS) paralogs SRGAP2B/C are not only expressed in cortical neurons but are the only HS gene duplications expressed in human micr...

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Literature Corpus work: eb43fb3d-46a4-5d1f-bb32-f9b6b793a74c
DOI: 10.1101/2024.06.28.601266

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