Article

Human synaptic neoteny requires species-specific balancing of SRGAP2-SYNGAP1 cross-inhibition

2023-03-02

Abstract excerpt

Human-specific (HS) genes are potential drivers of brain evolution, but their impact on human neuron development and disease remains unclear. Here we studied HS genes SRGAP2B/C in human cortical projection neurons (CPNs) in vivo, using xenotransplantation in the mouse cortex. Downregulation of SRGAP2B/C in human CPNs greatly accelerated synaptic development, indicating their requirement for human-specific synaptic...

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Literature Corpus work: e23129e9-63a6-51c8-bc59-de8372f5f679
DOI: 10.1101/2023.03.01.530630

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