Article

Heterogeneity in PHGDH protein expression potentiates cancer cell dissemination and metastasis

2021-01-26

Abstract excerpt

Cancer metastasis requires the transient activation of cellular programs enabling dissemination and seeding in distant organs. Genetic, transcriptional and translational intra-tumor heterogeneity contributes to this dynamic process. Beyond this, metabolic intra-tumor heterogeneity has also been observed, yet its role for cancer progression remains largely elusive. Here, we discovered that intra-tumor heterogeneity...

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Literature Corpus work: eb3e54c1-8dda-50e1-b0dc-d4cbeedd8cae
DOI: 10.1101/2021.01.24.427949

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