Radiogenomic-based multiomic analysis reveals imaging intratumor heterogeneity phenotypes and therapeutic targets.

doi:10.1126/sciadv.adf0837

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Article

Radiogenomic-based multiomic analysis reveals imaging intratumor heterogeneity phenotypes and therapeutic targets.

Science advances - 6 Oct 2023

Su Guan-Hua, Xiao Yi, You Chao, Zheng Ren-Cheng, Zhao Shen, Sun Shi-Yun, Zhou Jia-Yin, Lin Lu-Yi, Wang He, Shao Zhi-Ming, Gu Ya-Jia, Jiang Yi-Zhou

Abstract excerpt

Intratumor heterogeneity (ITH) profoundly affects therapeutic responses and clinical outcomes. However, the widespread methods for assessing ITH based on genomic sequencing or pathological slides, which rely on limited tissue samples, may lead to inaccuracies due to potential sampling biases. Using a newly established multicenter breast cancer radio-multiomic dataset (n = 1474) encompassing radiomic features...

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PMID: 37801493
DOI: 10.1126/sciadv.adf0837
PMCID: PMC10558123

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