Article

Dissecting the contributions of tumor heterogeneity on metastasis at single-cell resolution

2022-08-05

Abstract excerpt

Metastasis is the leading cause of cancer-related deaths, but metastasis research is challenged by limited access to patient material and a lack of experimental models that appropriately recapitulate tumor heterogeneity. Here, we analyzed single-cell transcriptomes of matched primary tumor and metastasis from patient-derived xenograft models of breast cancer, demonstrating that primary tumor and metastatic cells s...

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Literature Corpus work: 3724a5f8-48ee-5e06-aa12-063546123e03
DOI: 10.1101/2022.08.04.502697

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