Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Immunoregulatory Protein B7-H3 Reprograms Glucose Metabolism in Cancer Cells by ROS-Mediated Stabilization of HIF1α

6 Apr 2016

Abstract excerpt

B7-H3 is a member of B7 family of immunoregulatory transmembrane glycoproteins expressed by T cells. While B7-H3 overexpression is associated with poor outcomes in multiple cancers, it also has immune-independent roles outside T cells and its precise mechanistic contributions to cancer are unclear. In this study, we investigated the role of B7-H3 in metabolic reprogramming of cancer cells in vitro and in vivo We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Cancer-related Molecular Pathways
Share to Metabolism, Diabetes, and Cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27197253
DOI: 10.1158/0008-5472.can-15-1538

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Immunoregulatory Protein B7-H3 Reprograms Glucose Metabolism in Cancer Cells by ROS-Mediated Stabilization of HIF1αPMID 27197253Read ↗

The novel non‐immunological role and underlying mechanisms of B7‐H3 in tumorigenesisSemantic proximity Read ↗

B7-H3 promotes aerobic glycolysis and chemoresistance in colorectal cancer cells by regulating HK2Semantic proximity Read ↗

Cancer cell-associated cytoplasmic B7–H4 is induced by hypoxia through hypoxia-inducible factor-1α and promotes cancer cell proliferationSemantic proximity Read ↗

Decreased expression of B7-H3 reduces the glycolytic capacity and sensitizes breast cancer cells to AKT/mTOR inhibitorsSemantic proximity Read ↗

B7H3 regulates differentiation and serves as a potential biomarker and theranostic target for human glioblastomaSemantic proximity Read ↗

RBBP4 orchestrates glycolytic reprogramming and NF-κB-mediated immune evasion in triple-negative breast cancerSemantic proximity Read ↗

Lactate-Driven Heterogeneity of Immune Checkpoint Expression in Breast and Lung Cancer Cell LinesSemantic proximity Read ↗

ALDH1A1 promotes immune escape of tumor cells through ZBTB7B-glycolysis pathwaySemantic proximity Read ↗

Interplay between Immune Checkpoint Proteins and Cellular MetabolismSemantic proximity Read ↗

Targeting B7-H1 (PD-L1) sensitizes cancer cells to chemotherapySemantic proximity Read ↗

To kill a cancer: Targeting the immune inhibitory checkpoint molecule, B7-H3Semantic proximity Read ↗

GPR81-mediated reprogramming of glucose metabolism contributes to the immune landscape in breast cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.