Article
Targeting PHGDH reverses the immunosuppressive phenotype of tumor-associated macrophages through α-ketoglutarate and mTORC1 signaling.
Cellular & molecular immunology - 1 May 2024
Cai Zhengnan, Li Wan, Hager Sonja, Wilson Jayne Louise, Afjehi-Sadat Leila, Heiss Elke H, Weichhart Thomas, Heffeter Petra, Weckwerth Wolfram
Abstract excerpt
Phosphoglycerate dehydrogenase (PHGDH) has emerged as a crucial factor in macromolecule synthesis, neutralizing oxidative stress, and regulating methylation reactions in cancer cells, lymphocytes, and endothelial cells. However, the role of PHGDH in tumor-associated macrophages (TAMs) is poorly understood. Here, we found that the T helper 2 (Th2) cytokine interleukin-4 and tumor-conditioned media upregulate the...
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