Article

Pyruvate carboxylase supports the pulmonary tropism of metastatic breast cancer

2018-05-15

Abstract excerpt

<h4>Background: </h4> Overcoming systemic dormancy and initiating secondary tumor grow under unique microenvironmental conditions is a major rate-limiting step in metastatic progression. Disseminated tumor cells encounter major changes in nutrient supplies and oxidative stresses compared to the primary tumor and must demonstrate significant metabolic plasticity to adapt to specific metastatic sites. Recent studies...

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Literature Corpus work: 0e59771e-da77-5d1f-b1fb-0843f4df0ba5
DOI: 10.1101/317743

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