Article
A LRRK2/dLRRK-mediated lysosomal pathway that contributes to glial cell death and DA neuron survival.
Traffic (Copenhagen, Denmark) - 1 Oct 2022
Wang Linfang, Wang Honglei, Yi Shuanglong, Zhang Shiping, Ho Margaret S
Abstract excerpt
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial and sporadic Parkinson's disease. A plethora of evidence has indicated a role for LRRK2 in endolysosomal trafficking in neurons, while LRRK2 function in glia, although highly expressed, remains largely unknown. Here, we present evidence that LRRK2/dLRRK mediates a lysosomal pathway that contributes to glial cell death and the...
Topics
- Cathepsin B
- Cell Death
- Dopaminergic Neurons
- Leucine
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Lysosomes
- Mutation
- Neuroglia