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DYRK1A promotes dopaminergic neuron survival in the developing brain and in a mouse model of Parkinson’s disease

12 Jun 2014

Abstract excerpt

In the brain, programmed cell death (PCD) serves to adjust the numbers of the different types of neurons during development, and its pathological reactivation in the adult leads to neurodegeneration. Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (DYRK1A) is a pleiotropic kinase involved in neural proliferation and cell death, and its role during brain growth is evolutionarily conserved. Human...

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PMID: 24922073
DOI: 10.1038/cddis.2014.253

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