Article
Elevated NEGR1 in brain induces anxiety or depression-like phenotypes and synaptic dysfunction.
Molecular psychiatry - 1 Oct 2025
Zhang Ya-Qi, Zhang Qing, Yang Yi, Yu Li-Li, Fan Ning-Lin, Wu Yong, Wang Jun-Yang, Dang Xing-Lun, Guo Ying-Qi, Li Cong, Ma Guo-Lan, Wang Lu, Guo Yong-Bo, Li Shi-Wu
Abstract excerpt
Single nucleotide polymorphisms (SNPs) within 1p31.1 region have shown significant associations with depression, and our prior functional genomics pinpointed a regulatory variant rs3101339 among them. However, its precise role in depression pathogenesis remains elusive. In this study, we employed a series of analytical and functional approaches, including regulatory element annotation, brain expression...
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