Article

Analyzing human knockouts to validate GPR151 as a therapeutic target for reduction of body mass index

2021-10-26

Abstract excerpt

Novel drug targets for sustained reduction in body mass index (BMI) are needed to curb the epidemic of obesity, which affects 650 million individuals worldwide and is a causal driver of cardiovascular and metabolic disease and mortality. Previous studies reported that the Arg95Ter nonsense variant of GPR151, an orphan G protein-coupled receptor, is associated with reduced BMI and reduced risk of Type 2 Diabetes (T...

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Literature Corpus work: b82646ac-186d-5c10-9c9b-82c89ebcbd6b
DOI: 10.1101/2021.10.21.21264378

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