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GPR75: Advances, Challenges in Deorphanization, and Potential as a Novel Drug Target for Disease Treatment

25 Apr 2025

Abstract excerpt

G protein-coupled receptor 75 (GPR75), a novel member of the rhodopsin-like G protein-coupled receptor (GPCR) family, has been identified across various tissues and organs, where it contributes to biological regulation and disease progression. Recent studies suggest potential interactions between GPR75 and ligands such as 20-hydroxyeicosatetraenoic acid (20-HETE) and C-C motif chemokine ligand 5 (CCL5/RANTES);...

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PMID: 40362321
DOI: 10.3390/ijms26094084

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