Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Orphan Receptor GPR151: Discovery, Expression, and Emerging Biological Significance

28 Apr 2025

Abstract excerpt

G protein-coupled receptors (GPCRs) are among the most prominent druggable targets in the human genome, accounting for approximately 40% of marketed drugs. Despite this, current GPCR-targeted therapies address only about 10% of the GPCRs encoded in the genome. Expanding our knowledge of the remaining "orphan" GPCRs represents a critical frontier in drug discovery. GPR151 emerges as a compelling target due to its...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes Treatment and Management
Share to Neuropeptides and Animal Physiology
Share to Receptor Mechanisms and Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40295925
DOI: 10.1021/acschemneuro.4c00780

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Orphan Receptor GPR151: Discovery, Expression, and Emerging Biological SignificancePMID 40295925Read ↗

The role of orphan G protein-coupled receptors in painSemantic proximity Read ↗

GPR75: Advances, Challenges in Deorphanization, and Potential as a Novel Drug Target for Disease TreatmentSemantic proximity Read ↗

The Habenular Receptor GPR151 Regulates Addiction Vulnerability Across Drug ClassesSemantic proximity Read ↗

G protein-coupled receptor 35: an emerging target in inflammatory and cardiovascular diseaseSemantic proximity Read ↗

A habenula-enriched GPCR, GPR151, regulates behavioral sensitivity to inflammationSemantic proximity Read ↗

G‐protein‐coupled receptors: past, present and futureSemantic proximity Read ↗

Rare GPR37L1 variants reveal potential roles in anxiety and migraine disordersSemantic proximity Read ↗

Targeted disruption of the orphan receptor Gpr151 does not alter pain-related behaviour despite a strong induction in dorsal root ganglion expression in a model of neuropathic pain.Semantic proximity Read ↗

Orphan G-Protein Coupled Receptor GPRC5B Is Critical for Lymphatic DevelopmentSemantic proximity Read ↗

Orphan G Protein Coupled Receptors in Affective Disorders.Semantic proximity Read ↗

Emerging roles of a chemoattractant receptor GPR15 and ligands in pathophysiologySemantic proximity Read ↗

Key aspects of modern GPCR drug discoverySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.