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Article

Inferring cell-type-specific causal gene regulatory networks during human neurogenesis.

Genome biology - 30 May 2023

Aygün Nil, Liang Dan, Crouse Wesley L, Keele Gregory R, Love Michael I, Stein Jason L

Abstract excerpt

BACKGROUND: Genetic variation influences both chromatin accessibility, assessed in chromatin accessibility quantitative trait loci (caQTL) studies, and gene expression, assessed in expression QTL (eQTL) studies. Genetic variants can impact either nearby genes (cis-eQTLs) or distal genes (trans-eQTLs). Colocalization between caQTL and eQTL, or cis- and trans-eQTLs suggests that they share causal variants. However,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37254169
DOI: 10.1186/s13059-023-02959-0
PMCID: PMC10230710

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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