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Article

Developmental isoform diversity in the human neocortex informs neuropsychiatric risk mechanisms.

Science (New York, N.Y.) - 24 May 2024

Patowary Ashok, Zhang Pan, Jops Connor, Vuong Celine K, Ge Xinzhou, Hou Kangcheng, Kim Minsoo, Gong Naihua, Margolis Michael, Vo Daniel, Wang Xusheng, Liu Chunyu, Pasaniuc Bogdan, Li Jingyi Jessica, Gandal Michael J, de la Torre-Ubieta Luis

Abstract excerpt

RNA splicing is highly prevalent in the brain and has strong links to neuropsychiatric disorders; yet, the role of cell type-specific splicing and transcript-isoform diversity during human brain development has not been systematically investigated. In this work, we leveraged single-molecule long-read sequencing to deeply profile the full-length transcriptome of the germinal zone and cortical plate regions of the...

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PMID: 38781356
DOI: 10.1126/science.adh7688

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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