Article

Developmental isoform diversity in the human neocortex informs neuropsychiatric risk mechanisms

2023-03-26

Abstract excerpt

RNA splicing is highly prevalent in the brain and has strong links to neuropsychiatric disorders, yet the role of cell-type-specific splicing or transcript-isoform diversity during human brain development has not been systematically investigated. Here, we leveraged single-molecule long-read sequencing to deeply profile the full-length transcriptome of the germinal zone (GZ) and cortical plate (CP) regions of the d...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4a14e4ce-5c3c-57ba-99d8-23ae0d8de4e5
DOI: 10.1101/2023.03.25.534016

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Developmental isoform diversity in the human neocortex informs neuropsychiatric risk mechanismsDOI 10.1101/2023.03.25.534016Read

Developmental isoform diversity in the human neocortex informs neuropsychiatric risk mechanisms.Semantic proximity Read

Long-read proteogenomic atlas of human neuronal differentiation reveals isoform diversity informing neurodevelopmental risk mechanismsSemantic proximity Read

Cross-ancestry, cell-type-informed atlas of gene, isoform, and splicing regulation in the developing human brainSemantic proximity Read

Long-read transcriptomics of purified human cortical cell types exposes glial isoform complexity and disease-relevant transcript architectureSemantic proximity Read

Genetic control of gene expression and splicing in the developing human brainSemantic proximity Read

Whole-genome and RNA sequencing reveal variation and transcriptomic coordination in the developing human prefrontal cortexSemantic proximity Read

A spatial long-read approach at near-single-cell resolution reveals developmental regulation of splicing and polyadenylation sites in distinct cortical layers and cell typesSemantic proximity Read

Long-read sequencing reveals the RNA isoform repertoire of neuropsychiatric risk genes in human brainSemantic proximity Read

An atlas of expressed transcripts in the prenatal and postnatal human cortexSemantic proximity Read

Full-length transcript sequencing of human and mouse identifies widespread isoform diversity and alternative splicing in the cerebral cortexSemantic proximity Read

Deciphering Cell-Type and Temporal-Specific Matrisome Expression Signatures in Human Cortical Development and Neurodevelopmental Disorders via scRNA-Seq Meta-AnalysisSemantic proximity Read

A single cell transcriptomic analysis of human neocortical developmentSemantic proximity Read