Adaptive variation in human toll-like receptors is contributed by introgression from both Neandertals and Denisovans

Abstract excerpt

Pathogens and the diseases they cause have been among the most important selective forces experienced by humans during their evolutionary history. Although adaptive alleles generally arise by mutation, introgression can also be a valuable source of beneficial alleles. Archaic humans, who lived in Europe and Western Asia for over 200,000 years, were likely well-adapted to the environment and its local pathogens, an...

Topics

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• Adaptation, Physiological
• Cell Line
• Genome-Wide Association Study
• Haplotypes
• Neanderthals
• Polymorphism, Single Nucleotide
• Selection, Genetic
• Toll-Like Receptors

Identifiers and source

Literature Corpus work

eb11251b-14e0-551c-ab0a-98b361a1a897

DOI

10.1101/022699